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与免疫抑制剂及肿瘤坏死因子-α拮抗剂治疗相关的播散性孢子丝菌病

Disseminated sporotrichosis associated with treatment with immunosuppressants and tumor necrosis factor-alpha antagonists.

作者信息

Gottlieb Geoffrey S, Lesser Cammie F, Holmes King K, Wald Anna

机构信息

Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195, USA.

出版信息

Clin Infect Dis. 2003 Sep 15;37(6):838-40. doi: 10.1086/377235. Epub 2003 Aug 23.

DOI:10.1086/377235
PMID:12955647
Abstract

We report a case of disseminated sporotrichosis in a 49-year-old man who was treated with multiple immunosuppressants, including tumor necrosis factor (TNF)-alpha antagonists (etanercept and infliximab), for presumed inflammation arthritis. This case illustrates the potential for infectious complications related to the use of cytotoxic immunosuppressants and anticytokine agents, such as TNF-alpha antagonists.

摘要

我们报告一例49岁男性播散性孢子丝菌病病例，该患者因疑似炎症性关节炎接受了多种免疫抑制剂治疗，包括肿瘤坏死因子（TNF）-α拮抗剂（依那西普和英夫利昔单抗）。该病例说明了使用细胞毒性免疫抑制剂和抗细胞因子药物（如TNF-α拮抗剂）可能引发感染并发症。

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Clin Infect Dis. 2003 Sep 15;37(6):838-40. doi: 10.1086/377235. Epub 2003 Aug 23.
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