Matsuzaka Kenichi, Koike Yoshihiko, Yakushiji Takashi, Shimono Masaki, Inoue Takashi
Department of Clinical Pathophysiology, Oral Health Science Center, Tokyo Dental College, 1-2-2 Masago, Mihama-ku, Chiba 261-8502, Japan.
Bull Tokyo Dent Coll. 2003 May;44(2):55-9. doi: 10.2209/tdcpublication.44.55.
We report a rare case of intravascular papillary endothelial hyperplasia (IPEH) arising from the upper lip. Pathologically, it consisted of a few lobulated masses lined by an incomplete fibrous capsule of variable thickness which was separated from the surrounding tissue and which partially formed papillary structures bearing fibrous stalks and a single layer of endothelium. The capillary formation was poorly defined, and mitotic figures were frequently observed. Immunohistochemically, the endothelial cells were positive for factor VIII related antigen and vimentin, and many cells were positive for PCNA, not only in the solid proliferating area but also in the papillary proliferating area. This case represents IPEH with high proliferative activity.
我们报告了一例罕见的起源于上唇的血管内乳头状内皮增生（IPEH）病例。病理上，它由几个分叶状肿块组成，周围有一层厚度不一的不完整纤维包膜，与周围组织分隔开，部分形成带有纤维蒂和单层内皮的乳头状结构。毛细血管形成不清晰，且经常观察到有丝分裂象。免疫组织化学检查显示，内皮细胞对因子VIII相关抗原和波形蛋白呈阳性反应，许多细胞对增殖细胞核抗原（PCNA）呈阳性反应，不仅在实性增殖区域，在乳头状增殖区域也是如此。该病例代表具有高增殖活性的IPEH。
