Albrecht S, Kahn H J
Department of Pathology, Women's College Hospital, University of Toronto, Ontario, Canada.
J Cutan Pathol. 1990 Feb;17(1):16-21. doi: 10.1111/j.1600-0560.1990.tb01672.x.
Intravascular papillary endothelial hyperplasia is an interesting endothelial proliferation, the nature of which has aroused some controversy. Five cases were studied by light microscopy and by immunohistochemistry using antibodies to Factor VIII-related antigen (FVIII-rAg), ferritin, alpha 1-antitrypsin, alpha 1-antichymotrypsin and vimentin and were compared with conventional intravascular organizing thrombi. The results show a similar progression of the immunophenotype of the endothelial cells in both entities: they are initially positive for ferritin, then acquire vimentin positivity and only display FVIII-rAg positivity in advanced ("mature") lesions. This suggests that intravascular endothelial hyperplasia is closely related to organizing thrombi and is probably a peculiar form thereof.
血管内乳头状内皮细胞增生是一种有趣的内皮细胞增殖，其性质引发了一些争议。通过光学显微镜和免疫组织化学方法，使用针对VIII因子相关抗原（FVIII-rAg）、铁蛋白、α1-抗胰蛋白酶、α1-抗糜蛋白酶和波形蛋白的抗体，对5例病例进行了研究，并与传统的血管内机化血栓进行了比较。结果显示，两种病变中内皮细胞的免疫表型变化过程相似：它们最初对铁蛋白呈阳性，随后获得波形蛋白阳性，仅在晚期（“成熟”）病变中显示FVIII-rAg阳性。这表明血管内内皮细胞增生与机化血栓密切相关，可能是其一种特殊形式。
