卡马西平诱发的系统性红斑狼疮样疾病。

Carbamazepine-induced systemic lupus erythematosus-like disease.

作者信息

Kanno T, Miyata M, Kazuta Y, Sato Y, Nishimaki T, Kasukawa R

机构信息

Department of Internal Medicine II, Fukushima Medical College, Japan.

出版信息

Intern Med. 1992 Nov;31(11):1303-5. doi: 10.2169/internalmedicine.31.1303.

DOI:10.2169/internalmedicine.31.1303

PMID:1295628

Abstract

A 14-year-old female developed systemic lupus erythematosus (SLE)-like symptoms, rash, fever, leukopenia and positive anti-nuclear antibody (ANA) two weeks after administration of carbamazepine (CBZ; Tegretol) used against benign Rolandic epilepsy. Clinical symptoms and leukopenia normalized after discontinuation of CBZ and administration of prednisolone at 40 mg. The cases of CBZ-induced SLE reported in the literature were reviewed.

摘要

一名14岁女性在服用用于治疗良性罗兰德癫痫的卡马西平（CBZ；得理多）两周后出现了系统性红斑狼疮（SLE）样症状、皮疹、发热、白细胞减少以及抗核抗体（ANA）阳性。停用CBZ并给予40毫克泼尼松龙后，临床症状和白细胞减少恢复正常。对文献中报道的卡马西平诱发系统性红斑狼疮的病例进行了回顾。