Hsu Karl, Look A Thomas
Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA.
Cancer Cell. 2003 Aug;4(2):81-3. doi: 10.1016/s1535-6108(03)00192-2.
In this issue of Cancer Cell, demonstrate a novel mechanism for the oncogenic activity of MLL chimeric proteins. By providing coiled-coil or other dimerization domains, the cytoplasmic partners of MLL fusion proteins donate a platform for MLL homodimerization, allowing recruitment of accessory factors needed to activate the critical downstream targets, including selected subsets of the major HOX genes.
在本期《癌细胞》杂志中，展示了MLL嵌合蛋白致癌活性的一种新机制。通过提供卷曲螺旋或其他二聚化结构域，MLL融合蛋白的胞质伴侣为MLL同二聚化提供了一个平台，从而能够募集激活关键下游靶点（包括主要HOX基因的选定亚群）所需的辅助因子。
