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酒精性肝病中的肝脏铁过载:为何会发生以及其在发病机制中的作用是什么?

Hepatic iron overload in alcoholic liver disease: why does it occur and what is its role in pathogenesis?

作者信息

Rouault Tracey A

机构信息

Section on Human Iron Metabolism, Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, Building 18, Room 101, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Alcohol. 2003 Jun;30(2):103-6. doi: 10.1016/s0741-8329(03)00102-2.

DOI:10.1016/s0741-8329(03)00102-2
PMID:12957293
Abstract

Iron overload is frequently observed in alcoholic liver disease. However, it is not known why hepatic iron accumulation occurs or how it contributes to disease progression. In this review, information about the role of iron in the pathophysiology of liver disease is reviewed and discussed.

摘要

铁过载在酒精性肝病中经常被观察到。然而,尚不清楚肝脏铁蓄积为何会发生,以及它如何促进疾病进展。在这篇综述中,我们对铁在肝病病理生理学中的作用的相关信息进行了综述和讨论。

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Hepatic iron overload in alcoholic liver disease: why does it occur and what is its role in pathogenesis?酒精性肝病中的肝脏铁过载:为何会发生以及其在发病机制中的作用是什么?
Alcohol. 2003 Jun;30(2):103-6. doi: 10.1016/s0741-8329(03)00102-2.
2
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[The effect of alcohol on the regulation of iron metabolism].[酒精对铁代谢调节的影响]
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Role of alcohol in the regulation of iron metabolism.酒精在铁代谢调节中的作用。
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CHOP-mediated hepcidin suppression modulates hepatic iron load.CHOP 介导的铁调素抑制调节肝脏铁负荷。
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Liver hepcidin mRNA expression is inappropriately low in alcoholic patients compared with healthy controls.与健康对照组相比,酒精性肝病患者肝组织中hepcidin mRNA 的表达水平异常降低。
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Vitamin C protective role for alcoholic liver disease in mice through regulating iron metabolism.维生素C通过调节铁代谢对小鼠酒精性肝病起到保护作用。
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Iron overload in alcoholic liver disease: underlying mechanisms, detrimental effects, and potential therapeutic targets.酒精性肝病中的铁过载:潜在机制、有害影响和潜在治疗靶点。
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Decreased hepatic iron in response to alcohol may contribute to alcohol-induced suppression of hepcidin.酒精作用下肝脏铁含量降低可能导致酒精诱导的铁调素抑制。
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The Emerging Role of Ferroptosis in Liver Diseases.铁死亡在肝脏疾病中的新兴作用
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The effect of food and nutrients on iron overload: what do we know so far?食物和营养素对铁过载的影响:我们目前了解多少?
Eur J Clin Nutr. 2021 Dec;75(12):1771-1780. doi: 10.1038/s41430-021-00887-5. Epub 2021 Mar 12.
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Iron elevates mesenchymal and metastatic biomarkers in HepG2 cells.铁升高 HepG2 细胞中的间充质和转移生物标志物。
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Deregulation of Hepatic Mek1/2⁻Erk1/2 Signaling Module in Iron Overload Conditions.铁过载条件下肝脏Mek1/2⁻Erk1/2信号模块的失调
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PLoS One. 2015 Aug 13;10(8):e0135486. doi: 10.1371/journal.pone.0135486. eCollection 2015.
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Combination of alcohol and fructose exacerbates metabolic imbalance in terms of hepatic damage, dyslipidemia, and insulin resistance in rats.酒精和果糖的组合会加剧大鼠肝脏损伤、血脂异常和胰岛素抵抗方面的代谢失衡。
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