Centeno José A, Pestaner Joseph P, Omalu Bennet I, Torres Norca L, Field Frances, Wagner Glenn, Mullick Florabel G
Department of Environmental and Toxicologic Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.
Biol Trace Elem Res. 2003 Aug;94(2):97-104. doi: 10.1385/BTER:94:2:97.
Complementary alternative medicine therapies based on the use of cesium chloride preparations for the treatment of cancer and radiation poisoning, have generated therapeutic interest; but oral or intravenous administration of cesium chloride (CsCl) to cancer patients as an alternative mode of cancer therapy have not been approved by the US Food and Drug Administration (FDA).
Cesium (Cs) levels from human tissue were measured to determine exposure to an alternative medical treatment. Cesium levels are reported from two patients who were administered cesium chloride in conjunction with aloe vera as part of an alternative cancer treatment.
The samples were analyzed by graphite furnace atomic absorption spectrometry with Zeeman background correction. As a reference, Cs was also determined in brain, liver, kidney, and whole blood from control case materials retrieved from the National Tissue Repository of the Armed Forces Institute of Pathology.
High levels of cesium were found in brain, liver, kidney, bile, gastric content, and whole blood collected at autopsy as compared to reference levels. The administration of cesium chloride resulted in blood levels a factor of 1100 higher than normal. The highest Cs concentrations were found in the liver (1029 microg/g, dry wt), followed by the kidney (815 microg/g, dry wt) and brain (219 microg/g, dry wt).
The high accumulation in the liver suggests that hepatotoxicity from Cs might be an initial presenting symptom in Cs-poisoning cases. This is the first report describing two cases with high Cs levels in human tissues.
基于使用氯化铯制剂治疗癌症和辐射中毒的补充替代医学疗法引起了治疗兴趣；但作为癌症治疗的替代模式，向癌症患者口服或静脉注射氯化铯（CsCl）尚未得到美国食品药品监督管理局（FDA）的批准。
测量人体组织中的铯（Cs）水平，以确定对一种替代医学治疗的暴露情况。报告了两名患者的铯水平，他们接受了氯化铯与芦荟联合治疗，作为替代癌症治疗的一部分。
采用带塞曼背景校正的石墨炉原子吸收光谱法对样品进行分析。作为对照，还测定了从武装部队病理研究所国家组织库获取的对照病例材料的脑、肝、肾和全血中的铯。
与对照水平相比，尸检时采集的脑、肝、肾、胆汁、胃内容物和全血中发现了高水平的铯。氯化铯的给药导致血液水平比正常水平高1100倍。铯浓度最高的是肝脏（1029微克/克，干重），其次是肾脏（815微克/克，干重）和脑（219微克/克，干重）。
肝脏中的高蓄积表明，铯引起的肝毒性可能是铯中毒病例的最初表现症状。这是首次描述两例人体组织中铯水平高的病例报告。
