Bertho Jean-Marc, Louiba Sonia, Faure Marie-Cécile, Tourlonias Elie, Stefani Johanna, Siffert Baptiste, Paquet François, Dublineau Isabelle
Laboratoire de radiotoxicologie expérimentale DRPH/SRBE, LRTOX, IRSN, BP no. 17, 92262, Fontenay aux roses Cedex, France.
Radiat Environ Biophys. 2010 May;49(2):239-48. doi: 10.1007/s00411-010-0267-3. Epub 2010 Feb 16.
The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of (137)Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq l(-1). Ingestion started in parent animals before mating, and (137)Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. (137)Cs content was measured in various organs, indicating that (137)Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although (137)Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function.
这项工作的目的是确定长期摄入（137）铯过程中血液学变化的可能发生情况。使用了小鼠模型，通过饮用铯浓度为20 kBq l(-1)的水进行摄入。在亲代动物交配前开始摄入，并在出生至20周龄的不同年龄段的后代中研究（137）铯的摄入量及其对造血系统的影响。测量了各个器官中的（137）铯含量，表明（137）铯分布于整个机体，包括淋巴造血器官，即股骨、脾脏和胸腺。然而，无论使用何种参数，我们均未观察到对造血系统有任何影响。事实上，与对照动物相比，血细胞计数、单核细胞计数以及骨髓和脾脏中的祖细胞频率，以及血浆中的Flt3配体、促红细胞生成素、粒细胞集落刺激因子和基质细胞衍生因子-1浓度均保持不变。此外，表型分析未显示骨髓细胞群体比例有任何变化。这些结果表明，尽管在所有涉及造血系统的器官中都发现了（137）铯，但这并未引起骨髓功能的任何变化。
