Nugent A M, Neely D, Young I, McDowell I, O'Kane M, Bell N, Stanford C F, Nicholls D P
Royal Victoria Hospital, Belfast BT12 6BA, Northern Ireland.
Br J Clin Pharmacol. 1993 Nov;36(5):474-7. doi: 10.1111/j.1365-2125.1993.tb00400.x.
In order to determine whether treatment of hyperlipidaemia with simvastatin impairs exercise stress responses and so may contribute to an excess of suicides and violent deaths, the effects of simvastatin 20 mg daily and placebo on exercise physiology were compared in 19 patients. After 6 weeks of treatment there was no evidence of reduced exercise capacity, or of reduced cortisol or catecholamine responses. It is concluded that treatment of hyperlipidaemia with an inhibitor of HMG-CoA reductase does not significantly modify stress responses, and so the explanation for a possible increase in non-cardiac mortality must be sought elsewhere.
为了确定使用辛伐他汀治疗高脂血症是否会损害运动应激反应，进而可能导致自杀和暴力死亡人数过多，对19例患者比较了每日20毫克辛伐他汀和安慰剂对运动生理学的影响。治疗6周后，没有证据表明运动能力下降，或皮质醇或儿茶酚胺反应降低。结论是，用HMG-CoA还原酶抑制剂治疗高脂血症不会显著改变应激反应，因此必须在其他地方寻找非心脏性死亡率可能增加的原因。
