奥美拉唑和尼扎替丁对苯妥英处置（CYP2C活性标志物）无抑制作用。
Absence of an inhibitory effect of omeprazole and nizatidine on phenytoin disposition, a marker of CYP2C activity.
作者信息
Bachmann K A, Sullivan T J, Jauregui L, Reese J H, Miller K, Levine L
机构信息
The Center for Applied Pharmacology, The University of Toledo College of Pharmacy, Toledo, Ohio 43606, USA.
出版信息
Br J Clin Pharmacol. 1993 Oct;36(4):380-2. doi: 10.1111/j.1365-2125.1993.tb00382.x.
Abstract
The effects of omeprazole (40 mg orally per day) and nizatidine (300 mg orally per day) on the disposition of phenytoin (4.5 mg kg(-1) p.o. single dose) were studied in 18 healthy, young adult males. Total and unbound plasma concentrations of phenytoin were measured for 48 h after each dose of phenytoin. Neither treatment altered the disposition kinetics of phenytoin, the hydroxylation of which is mediated specifically by cytochromes P450 of the 2C subfamily.
摘要
在18名健康的年轻成年男性中研究了奥美拉唑（每日口服40毫克）和尼扎替丁（每日口服300毫克）对苯妥英（4.5毫克/千克口服单剂量）处置的影响。在每次服用苯妥英后48小时测量苯妥英的总血浆浓度和游离血浆浓度。两种治疗均未改变苯妥英的处置动力学，其羟基化由2C亚家族的细胞色素P450特异性介导。
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