Spicer E J, Maruden A, Terazawa K
International Research and Development Corp., Mattawan, MI 49071.
J Toxicol Sci. 1992 Dec;17 Suppl 4:101-23. doi: 10.2131/jts.17.supplementiv_101.
To assess the subacute toxicity of 6-amidino-2-naphthyl 4-[(4,5-dihydro-1H-imidazol-2-yl)amino] benzoate dimethanesulfonate (FUT-187) a 13 week subacute toxicity study by gavage was done in Cynomolgus monkeys at dosage levels of 0, 15, 45 and 135 mg/kg/day. Deaths were seen in the 135 mg/kg/day group; with associated debility. The animals that died had high plasma levels of FUT-187. Little weight gain was seen in the 135 mg/kg/day group. There were no clear treatment related effects on ophthalmoscopy or electrocardiography or on hematological, biochemical or urinalysis. There were no effects noted at necropsy or on histopathology and the causes of death for each of the 3 animals that died were suppurative glomerulonephritis, bone marrow depression and possible gavage injury respectively. The no-effect level for toxicology was considered to be 45 mg/kg/day.
为评估6-脒基-2-萘基4-[(4,5-二氢-1H-咪唑-2-基)氨基]苯甲酸二甲磺酸盐（FUT-187）的亚急性毒性，对食蟹猴进行了为期13周的经口亚急性毒性研究，剂量水平分别为0、15、45和135mg/kg/天。135mg/kg/天组出现死亡；伴有虚弱。死亡动物的FUT-187血浆水平较高。135mg/kg/天组体重增加很少。在检眼镜检查、心电图检查或血液学、生化或尿液分析方面，未发现与治疗相关的明显影响。尸检或组织病理学检查未发现影响，死亡的3只动物的死因分别为化脓性肾小球肾炎、骨髓抑制和可能的灌胃损伤。毒理学的无作用水平被认为是45mg/kg/天。
