Shimamura K, Terabayashi M, Kuramoto S, Hasegawa N, Terazawa K, Maruden A
Research Laboratories, Torii & Co., Ltd., Chiba, Japan.
J Toxicol Sci. 1992 Dec;17 Suppl 4:253-61. doi: 10.2131/jts.17.supplementiv_253.
Oral administration of 6-amidino-2-naphthyl 4(-)[(4,5-dihydro-1H-imidazol-2-yl)amino] benzoate dimethanesulfonate (FUT-187) at doses of 10, 30 and 100 mg/kg was given to New Zealand White rabbits on days 6 to 18 of gestation. The following results were obtained. Decreased food consumption and suppression of body weight gain in dams were observed and these changes contributed to the increase in aborted or prematured births and increased fetal mortality at the 100 mg/kg group. There were changes attributable to FUT-187 on external, skeletal and visceral examinations of fetuses. Based on the above, the no-effect dose level in dams and fetuses in the present study is 30 mg/kg/day.
在妊娠第6至18天，给新西兰白兔口服剂量为10、30和100mg/kg的6-脒基-2-萘基4-[(4,5-二氢-1H-咪唑-2-基)氨基]苯甲酸酯二甲磺酸盐（FUT-187）。获得了以下结果。观察到母兔的食物摄入量减少和体重增加受到抑制，这些变化导致100mg/kg组的流产或早产增加以及胎儿死亡率升高。在对胎儿进行外部、骨骼和内脏检查时，发现了与FUT-187有关的变化。基于以上情况，本研究中母兔和胎儿的无作用剂量水平为30mg/kg/天。
