Chen W H, Shih P Y
Department of Neurology, Kaohsiung Medical College, Taiwan, Republic of China.
Gaoxiong Yi Xue Ke Xue Za Zhi. 1992 Nov;8(11):581-4.
Ferrous ion is an essential cofactor in dopamine synthesis and its decrease may reduce the dopamine production in the nigrostriatal system, the basis of pathogenetic mechanism in Parkinson's disease (PD). Therefore, parkinsonians may have an abnormal systemic ferrokinetics. The serum iron, ferritin, total-iron-binding-capacity (TIBC) levels and transferrin saturation were analysed in 15 patients with Parkinson's disease and 30 controls. The serum iron was lower in PD (95.53 +/- 33.5 micrograms/dl) than in controls (102.5 +/- 32.5 micrograms/dl), but the difference was statistically nonsignificant. The ferritin, TIBC and transferrin saturation were also similar in both groups. The systemic ferrokinetics in our PD was normal, but the ferrokinetics between the central and systemic compartments was different in PD. Therefore, reduction of central dopamine in PD is unlikely due to hypoferruginemia.
亚铁离子是多巴胺合成中必不可少的辅助因子，其减少可能会降低黑质纹状体系统中的多巴胺生成，而这正是帕金森病（PD）发病机制的基础。因此，帕金森病患者可能存在异常的全身铁动力学。对15例帕金森病患者和30名对照者的血清铁、铁蛋白、总铁结合力（TIBC）水平及转铁蛋白饱和度进行了分析。帕金森病患者的血清铁（95.53±33.5微克/分升）低于对照组（102.5±32.5微克/分升），但差异无统计学意义。两组的铁蛋白、TIBC和转铁蛋白饱和度也相似。我们研究中的帕金森病患者全身铁动力学正常，但帕金森病患者中枢和全身 compartments 之间的铁动力学不同。因此，帕金森病中中枢多巴胺的减少不太可能是由于低铁血症。
