膳食铁与血清铁、机体铁储备及冠心病

Dietary and serum iron, body iron stores and coronary heart disease.

作者信息

Gupta R, Rastogi S, Nagar R, Kastia S, Kaul V

机构信息

Department of Medicine, Monilek Hospital and Research Centre, Jaipur.

出版信息

J Assoc Physicians India. 2000 May;48(5):489-92.

PMID:11273140

Abstract

OBJECTIVES

To determine the role of body-iron stores as measured by serum iron, total iron binding capacity (TIBC), transferrin, ferritin and ferritin:transferrin ratio (FTR) in patients with coronary heart disease (CHD).

METHODS

A case-control study was performed in 58 newly diagnosed CHD patients and 24 controls who were evaluated using clinical history, dietary history and biochemical examination. Dietary iron was determined by history; serum iron and TIBC were measured biochemically and ferritin by enzyme-linked immunoassay. Case-control comparisons were performed by non-parametric Mann-Whitney test.

RESULTS

There was no significant difference in mean age, prevalence of diabetes, hypertension and smoking, and dietary intake of calories and fats in cases and controls. Dietary iron intake was 11.2 +/- 3.4 mg/day in cases and 11.3 +/- 3.8 mg/day in controls (p > 0.05). Serum fasting glucose, cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were not significantly different in cases and controls (p > 0.05). LDL/HDL ratio (4.17 +/- 1.4 vs. 4.62 +/- 2.3) and total cholesterol/HDL ratio (6.47 +/- 1.6 vs. 6.91 +/- 2.4) were also similar. In the whole study group serum iron (54.8 +/- 35.7 mcg/dl), transferrin (11.6 +/- 7.4%) and ferritin (52.4 +/- 57.8 ng/ml) levels were low. In cases as compared to controls serum iron (56.9 +/- 31 vs. 49.6 +/- 45 mcg/dl; z = 1.707, p = 0.088) and transferrin saturation (12.5 +/- 7.8 vs. 9.5 +/- 6.2%; z = 1.83, p = 0.066) were slightly more. Ferritin levels (48.8 +/- 55 vs. 60.9 +/- 64 ng/ml; z = 2.048, p = 0.040) as well as FTR (5.51 +/- 8.6 vs 7.47 +/- 6.1, z = 2.054, p = 0.040) was significantly lower in cases.

CONCLUSIONS

In Indian CHD patients the body iron stores are lower as compared to controls.

摘要

目的

通过血清铁、总铁结合力（TIBC）、转铁蛋白、铁蛋白以及铁蛋白：转铁蛋白比值（FTR）来测定体内铁储备在冠心病（CHD）患者中的作用。

方法

对58例新诊断的冠心病患者和24例对照者进行病例对照研究，通过临床病史、饮食史和生化检查进行评估。通过病史确定饮食中铁的摄入量；采用生化方法测定血清铁和TIBC，采用酶联免疫吸附测定法测定铁蛋白。采用非参数曼-惠特尼检验进行病例对照比较。

结果

病例组和对照组在平均年龄、糖尿病患病率、高血压患病率、吸烟情况以及热量和脂肪的饮食摄入量方面无显著差异。病例组饮食中铁摄入量为11.2±3.4mg/天，对照组为11.3±3.8mg/天（p>0.05）。病例组和对照组的空腹血清葡萄糖、胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和甘油三酯无显著差异（p>0.05）。低密度脂蛋白/高密度脂蛋白比值（4.17±1.4对4.62±2.3）和总胆固醇/高密度脂蛋白比值（6.47±1.6对6.91±2.4）也相似。在整个研究组中，血清铁（54.8±35.7μg/dl）、转铁蛋白（11.6±7.4%）和铁蛋白（52.4±57.8ng/ml）水平较低。与对照组相比，病例组的血清铁（56.9±31对49.6±45μg/dl；z=1.707，p=0.088）和转铁蛋白饱和度（12.5±7.8对9.5±6.2%；z=1.83，p=0.066）略高。病例组的铁蛋白水平（48.8±55对60.9±64ng/ml；z=2.048，p=0.040）以及FTR（5.51±8.6对7.47±6.1，z=2.054，p=0.040）显著较低。