Marder K, Logroscino G, Tang M X, Graziano J, Cote L, Louis E, Alfaro B, Mejia H, Slavkovich V, Mayeux R
Gertrude H. Sergievsky Center, Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Neurology. 1998 Apr;50(4):1138-40. doi: 10.1212/wnl.50.4.1138.
Six measures of systemic iron metabolism were used to predict mortality among 103 patients with Parkinson's disease and 353 controls followed in a longitudinal study. Adjusting for gender, education, ethnicity, presence of dementia, and extrapyramidal signs, transferrin receptor concentration was strongly associated with mortality in patients with PD but not controls. This increase in serum transferrin receptor concentration before death suggests that the previously observed perturbation in iron metabolism continues throughout the disease course.
在一项纵向研究中，使用六项全身铁代谢指标来预测103例帕金森病患者和353例对照者的死亡率。在对性别、教育程度、种族、痴呆症的存在以及锥体外系体征进行校正后，转铁蛋白受体浓度与帕金森病患者的死亡率密切相关，而与对照组无关。死亡前血清转铁蛋白受体浓度的升高表明，先前观察到的铁代谢紊乱在整个疾病过程中持续存在。
