Cabrera-Valdivia F, Jiménez-Jiménez F J, Molina J A, Férnandez-Calle P, Vázquez A, Cañizares-Liébana F, Larumbe-Lobalde S, Ayuso-Peralta L, Rabasa M, Codoceo R
Department of Neurology, Hospital Universitario Príncipe de Asturias Alcalá de Henares, Madrid, Spain.
J Neurol Sci. 1994 Aug;125(1):82-6. doi: 10.1016/0022-510x(94)90246-1.
To elucidate the possible role of peripheral metabolism of iron in the risk for developing Parkinson's disease (PD), we compared serum levels of iron, transferrin and ferritin, and 24-h iron excretion in urine after a single intramuscular dose of 1 mg/kg desferrioxamine, in 68 PD patients and their spouses as the control group. All these values did not differ significantly between the groups, they were not influenced by antiparkinsonian therapy, and they did not correlate with age, age at onset and duration of the disease, scores of the Unified PD Rating Scale or the Hoehn and Yahr staging in the PD group, with the exception of the 24-h urinary iron excretion with the duration of the disease (r = 0.32, p < 0.05). These results suggest that peripheral metabolism of iron is apparently unrelated to the risk of developing PD.
为阐明铁的外周代谢在帕金森病（PD）发病风险中的可能作用，我们比较了68例PD患者及其作为对照组的配偶在单次肌肉注射1mg/kg去铁胺后血清中铁、转铁蛋白和铁蛋白水平，以及24小时尿铁排泄量。两组间所有这些值均无显著差异，它们不受抗帕金森病治疗的影响，且与年龄、发病年龄、病程、统一PD评定量表评分或PD组的Hoehn和Yahr分期均无相关性，但24小时尿铁排泄量与病程相关（r = 0.32，p < 0.05）。这些结果表明，铁的外周代谢显然与PD发病风险无关。
