Badgaiyan Rajendra D, Fischman Alan J, Alpert Nathaniel M
Division of Nuclear Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Neuroreport. 2003 Aug 6;14(11):1421-4. doi: 10.1097/00001756-200308060-00003.
Striatal dopamine is associated with the processing of rewarded motor tasks. Its involvement in mediating unrewarded tasks is, however, unclear. We used a recently developed PET technique to dynamically measure the rate of displacement of a dopamine receptor ligand raclopride in healthy volunteers performing a finger opposition task. Rapid displacement of the ligand from the posterior putamen and the caudate immediately after the task initiation suggested striatal dopamine release during task performance. Since dopamine release was observed in the striatal areas that are implicated in unrewarded tasks by neuroimaging studies, the results demonstrate that the PET method can be used to extend the findings of conventional neuroimaging techniques, that do not provide information about signal transduction.
纹状体多巴胺与奖赏性运动任务的处理相关。然而，其在介导无奖赏任务中的作用尚不清楚。我们使用一种最近开发的正电子发射断层扫描（PET）技术，动态测量了健康志愿者在执行手指对指任务时多巴胺受体配体雷氯必利的位移速率。任务开始后，配体从壳核后部和尾状核迅速位移，这表明在任务执行过程中纹状体多巴胺释放。由于在神经影像学研究中显示参与无奖赏任务的纹状体区域观察到了多巴胺释放，结果表明PET方法可用于扩展传统神经影像学技术的研究结果，传统神经影像学技术无法提供有关信号转导的信息。
