使用[¹¹C]雷氯必利测量在奖励性任务转换期间伏隔核中的多巴胺释放。
Dopamine release in nucleus accumbens during rewarded task switching measured by [¹¹C]raclopride.
作者信息
Jonasson Lars S, Axelsson Jan, Riklund Katrine, Braver Todd S, Ögren Mattias, Bäckman Lars, Nyberg Lars
机构信息
Department of Radiation Sciences, Umeå University, SE-901 87 Umeå, Sweden; Umeå Center for Functional Brain Imaging (UFBI), Umeå University, SE-901 87 Umeå, Sweden; Centre for Population Studies, Ageing and Living Conditions, Umeå University, SE-901 87 Umeå, Sweden.
Department of Radiation Sciences, Umeå University, SE-901 87 Umeå, Sweden.
出版信息
Neuroimage. 2014 Oct 1;99:357-64. doi: 10.1016/j.neuroimage.2014.05.047. Epub 2014 May 23.
Reward and motivation have positive influences on cognitive-control processes in numerous settings. Models of reward implicate corticostriatal loops and the dopamine (DA) system, with special emphasis on D2 receptors in nucleus accumbens (NAcc). In this study, 11 right-handed males (35-40 years) were scanned with positron emission tomography (PET) in a single [(11)C]raclopride dynamic scan during rewarded and non-rewarded task switching. Rewarded task switching (relative to baseline task switching) decreased [(11)C]raclopride binding in NAcc. Decreasing NAcc [(11)C]raclopride binding was strongly associated with task reaction time measures that reflect individual differences in effort and control strategies. Voxelwise analyses additionally revealed reward-related DA release in anterodorsal caudate, a region previously associated with task-switching. These PET findings provide evidence for striatal DA release during motivated cognitive control, and further suggest that NAcc DA release predicts the task reaction time benefits of reward incentives.
奖励和动机在众多情境中对认知控制过程具有积极影响。奖励模型涉及皮质纹状体回路和多巴胺（DA）系统，特别强调伏隔核（NAcc）中的D2受体。在本研究中，11名右利手男性（35 - 40岁）在奖励和无奖励任务切换的单次[（11）C]雷氯必利动态扫描中接受正电子发射断层扫描（PET）。奖励任务切换（相对于基线任务切换）降低了NAcc中[（11）C]雷氯必利的结合。NAcc中[（11）C]雷氯必利结合的降低与反映努力和控制策略个体差异的任务反应时间测量密切相关。体素分析还揭示了前背侧尾状核中与奖励相关的DA释放，该区域先前与任务切换有关。这些PET研究结果为动机性认知控制过程中纹状体DA释放提供了证据，并进一步表明NAcc DA释放可预测奖励激励带来的任务反应时间益处。
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