Monchi Oury, Ko Ji Hyun, Strafella Antonio P
Functional Neuroimaging Unit, University of Montréal, Montréal, Québec, Canada.
Neuroimage. 2006 Nov 15;33(3):907-12. doi: 10.1016/j.neuroimage.2006.06.058. Epub 2006 Sep 18.
To date, while the contribution of the striatum in executive processes is well documented, the role played by striatal dopamine during tasks requiring executive functions is still unknown. We used D2-dopamine receptor ligand [(11)C] raclopride PET in healthy subjects while performing the Montreal Card Sorting Task (MCST). We observed a striatal reduction in [(11)C] raclopride binding potential during planning of a set-shift when compared with matching according to an ongoing rule. These findings suggest that striatal dopamine neurotransmission increases significantly during the performance of specific executive processes confirming previous evidence of striatal activation during fMRI studies. The present observation may provide some insights on the origin of cognitive deficits underlying certain neurological disorders associated with dopamine dysfunction, such as Parkinson's disease.
迄今为止，虽然纹状体在执行功能过程中的作用已有充分记录，但在需要执行功能的任务中，纹状体多巴胺所起的作用仍不清楚。我们在健康受试者执行蒙特利尔卡片分类任务（MCST）时，使用D2-多巴胺受体配体[（11）C]雷氯必利PET进行研究。我们观察到，与根据现有规则进行匹配相比，在进行定势转换规划时，[（11）C]雷氯必利结合潜能在纹状体中降低。这些发现表明，在特定执行功能过程中，纹状体多巴胺神经传递显著增加，这证实了先前功能磁共振成像（fMRI）研究中纹状体激活的证据。目前的观察结果可能为某些与多巴胺功能障碍相关的神经疾病（如帕金森病）所潜在的认知缺陷的起源提供一些见解。
