Vannucci M, Dietl Th, Pezer N, Viggiano M P, Helmstaedter C, Schaller C, Elger C E, Grunwald Th
Department of Epileptology, University of Bonn, Germany.
Neuroreport. 2003 Aug 6;14(11):1489-92. doi: 10.1097/00001756-200308060-00017.
Limbic event-related potentials related to verbal but not to visual recognition memory have been found to be attenuated within the epileptic hippocampus of patients with temporal lobe epilepsy (TLE). To identify hippocampal contributions to visual processing and memory we recorded intracranial ERPs directly from within the epileptic and the non-epileptic hippocampus in 12 patients with unilateral TLE during a visual object decision and naming task. While the non-epileptic hippocampus differentiated reliably between real and nonsense objects, this effect was completely eliminated within the epileptic mesial temporal lobe. This finding suggests that the hippocampus proper contributes to the semantic processing of visual objects and may help to explain visual memory deficits in TLE.
已发现，与言语而非视觉识别记忆相关的边缘系统事件相关电位，在颞叶癫痫（TLE）患者的癫痫性海马体内会减弱。为了确定海马体对视觉处理和记忆的作用，我们在12名单侧TLE患者进行视觉物体判定和命名任务时，直接从癫痫性和非癫痫性海马体内记录了颅内事件相关电位。虽然非癫痫性海马体能可靠地区分真实物体和无意义物体，但在癫痫性内侧颞叶内，这种效应完全消失了。这一发现表明，海马体本身有助于视觉物体的语义处理，可能有助于解释TLE患者的视觉记忆缺陷。
