Jakubowska L, Szaflarska-Stojko E
Katedry Patologii Slaskiej Akademii, Medycznej w Katowicach.
Med Pr. 1992;43(6):479-83.
In order to evaluate biologically the action of two different kinds of talc pulmonary and hemolytic tests were applied and pathomorphological examination carried out on animals. The study was performed on 120 rats within the 6th and 9th months periods. The talcs used in the experiment did not indicate any fibrogenic properties. Morphologic examination did not show any differences in the pathogenetic activity between the Indian and Chinese talcs Inflammatory changes within the lungs and bronchi, pulmonary emphysema and increased levels of fibrosis indices in biochemical examinations have drawn our attention to problems connected with longterm exposure to talc dust.
为了从生物学角度评估两种不同滑石粉的作用,对动物进行了肺部和溶血试验,并进行了病理形态学检查。该研究在第6至9个月期间对120只大鼠进行。实验中使用的滑石粉未显示出任何致纤维化特性。形态学检查未显示印度滑石粉和中国滑石粉在致病活性上有任何差异。肺部和支气管内的炎症变化、肺气肿以及生化检查中纤维化指标水平的升高,使我们关注到与长期接触滑石粉尘相关的问题。