Andrzejak R, Tomczyk J, Antonowicz J, Lewczuk E, Beck B, Smolik R
Katedry i Kliniki Chorób Wewnetrznych i Zawodowych, Akademii Medycznej, Wrocławiu.
Med Pr. 1992;43(6):531-5.
The purpose of the study was to evaluate the general and toxicological status of footwear factory workers exposed to toluene, benzene and trace amounts of chromium. The subjects were 80 persons who worked with the glue, and were professionally exposed to aromatic hydrocarbons such as toluene and benzene AT amounts not exceeding the TLVs. The mean age of the subjects was 46.89 years and the mean period of work 20.26 years. Complete internal and neurological examinations were carried out. The following parameters were determined: hematocrit, hemoglobin, erythrocytes, leukocytes, platelets, reticulocytes, chromium, copper, zinc in serum and hippuric acid in urine (in 30 persons). In the examined group no changes in the leukocyte system were found. Two women had a lower hemoglobin level and erythrocyte count. In three persons thrombocytopenia was observed (3.75%). The mean metal levels in serum were within normal values. Only in 4 persons (5.0%) elevated levels of phenol in urine were found which indicated exposure to benzene. In 30 subjects (18 women and 12 men) (most exposed to toluene) the hippuric acid level in urine was examined. It was found to range from 130 mg/l to 2080 mg/l. In the control group not exposed to either of the solvents the level of hippuric acid in urine varied from 190 to 330 mg/l. There was little effect of aromatic hydrocarbons on hematopoiesis. The increased absorption of benzene or toluene found in the examined persons would indicate a necessity for biological monitoring of this group.
该研究的目的是评估接触甲苯、苯和微量铬的制鞋厂工人的一般健康状况和毒理学状况。研究对象为80名从事胶水工作的人员，他们职业性接触甲苯和苯等芳烃，接触量未超过阈限值。研究对象的平均年龄为46.89岁，平均工作年限为20.26年。进行了全面的内科和神经科检查。测定了以下参数：血细胞比容、血红蛋白、红细胞、白细胞、血小板、网织红细胞、血清中的铬、铜、锌以及尿中的马尿酸（30人）。在被检查组中未发现白细胞系统有变化。两名女性的血红蛋白水平和红细胞计数较低。三人出现血小板减少（3.75%）。血清中金属的平均水平在正常范围内。仅4人（5.0%）尿中苯酚水平升高，这表明接触了苯。对30名受试者（18名女性和12名男性）（大多数接触甲苯）的尿中马尿酸水平进行了检测。发现其范围为130毫克/升至2080毫克/升。在未接触任何一种溶剂的对照组中，尿中马尿酸水平在190至330毫克/升之间。芳烃对造血功能影响较小。在被检查人员中发现的苯或甲苯吸收增加表明有必要对该组进行生物监测。
