Wiwanitkit Viroj, Suwansaksri Jamsai, Srita Suriya, Fongsoongnern Anucha
Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
Southeast Asian J Trop Med Public Health. 2002 Sep;33(3):624-7.
Toluene is an important toxic volatile agent found in many modern industrial processes. Toluene exposure is of particular concern because of the ongoing exposure of thousands of workers in industrial plants and recent research has indicated that toluene/exposure can result in chronic toxicity. The monitoring and control of toluene exposure among at-risk workers is necessary. Urine hippuric acid determination is a helpful test monitoring groups of at-risk workers. In this study, urine samples were obtained from 20 control subjects and 48 press workers from a factory in Bangkok. Each subject gave a specimen of urine; each specimen was analyzed for hippuric acid level by the Ohmori method. The average urine hippuric acid level in the control group was 0.23 +/- 0.15 mg/gCr (range = 0.05 - 0.58 mg/gCr) while that of the experimental group was 0.37 +/- 0.37 mg/gCr (range = 0.06 - 0.18 mg/gCr). A significant higher urine hippuric acid level among the press workers was found (p = 0.03). Based on this study, the prevention of exposure to toluene among high-risk workers is recommended.
甲苯是一种在许多现代工业生产过程中发现的重要有毒挥发性物质。由于工业工厂中数千名工人持续接触甲苯，甲苯暴露问题备受关注，且近期研究表明，甲苯暴露会导致慢性毒性。对高危工人的甲苯暴露进行监测和控制很有必要。尿马尿酸测定是监测高危工人群体的一项有用检测。在本研究中，从曼谷一家工厂的20名对照受试者和48名印刷工人那里获取了尿液样本。每个受试者提供一份尿液标本；每份标本采用大森法分析马尿酸水平。对照组的尿马尿酸平均水平为0.23±0.15毫克/克肌酐（范围=0.05 - 0.58毫克/克肌酐），而实验组为0.37±0.37毫克/克肌酐（范围=0.06 - 0.18毫克/克肌酐）。发现印刷工人的尿马尿酸水平显著更高（p = 0.03）。基于本研究，建议对高危工人预防甲苯暴露。
