Ritter Matthew J, Goodman Brent P, Sprung Juraj, Wijdicks Eelco F M
Department of Anesthesiology, Mayo Clinic, Rochester, Minn. 55905, USA.
Mayo Clin Proc. 2003 Sep;78(9):1150-2. doi: 10.4065/78.9.1150.
We treated a patient who developed transient multifocal encephalopathy with extrapyramidal symptoms (oromandibular dystonia, oculogyric crisis, and limb dystonia) in temporal proximity to ondansetron administration on emergence from general anesthesia. No other medications known to cause extrapyramidal reactions were administered. Although these symptoms resolved fully, the presentation was dramatic and resembled the symptoms of structural brain injury. Ondansetron is used frequently as an antiemetic agent in many clinical settings and is not limited to surgical patients. Therefore, the entire medical community should be cognizant of this potential adverse reaction.
我们治疗了一名患者，该患者在全身麻醉苏醒后不久使用昂丹司琼后出现了伴有锥体外系症状（口下颌肌张力障碍、动眼危象和肢体肌张力障碍）的短暂性多灶性脑病。未使用其他已知可引起锥体外系反应的药物。尽管这些症状完全缓解，但临床表现很严重，类似于结构性脑损伤的症状。昂丹司琼在许多临床环境中经常用作止吐药，并不局限于外科手术患者。因此，整个医学界都应该认识到这种潜在的不良反应。
