成人在健康状态及病毒性呼吸道疾病期间细菌性中耳炎和鼻窦炎病原体的鼻咽部储存库
Nasopharyngeal reservoir of bacterial otitis media and sinusitis pathogens in adults during wellness and viral respiratory illness.
作者信息
Chi David H, Hendley J Owen, French Pamela, Arango Pablo, Hayden Frederick G, Winther Birgit
机构信息
Department of Otolaryngology-Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia 22906-0713, USA.
出版信息
Am J Rhinol. 2003 Jul-Aug;17(4):209-14.
BACKGROUND
The carriage rate of pathogenic bacteria in the nasopharynx (NP) was determined using three separate techniques for obtaining samples.
METHODS
The NP of 99 healthy adults was sampled with (1) nasal swab, (2) oral swab, and (3) nasal aspiration; 49 adults with common cold were sampled with an oral swab and nasal aspiration. Three selective agars were used to detect Streptococcus pneumoniae, Hemophilus influenzae, and Moraxella catarrhalis.
RESULTS
Seventy-three percent of healthy adults and 74% of cold sufferers had at least one pathogen detected in the NP. Detection rates were 65% (oral NP swab), 38% (catheter aspiration), and 28% (nasal swab; p < 0.001). Carriage rates for S. pneumoniae, M. catarrhalis, and H. influenzae were 45, 33, and 30%, respectively. Both a nasal and an oral sample were required for optimal detection.
CONCLUSION
Bacterial pathogens were present in the NP of three-quarters of adults during wellness and during colds.
背景
采用三种不同的样本采集技术测定鼻咽部（NP）致病细菌的携带率。
方法
对99名健康成年人的鼻咽部进行采样，采样方法包括：（1）鼻拭子；（2）口拭子；（3）鼻腔抽吸；对49名患普通感冒的成年人采用口拭子和鼻腔抽吸进行采样。使用三种选择性琼脂检测肺炎链球菌、流感嗜血杆菌和卡他莫拉菌。
结果
73%的健康成年人以及74%的感冒患者的鼻咽部检测到至少一种病原体。检测率分别为65%（口咽拭子）、38%（导管抽吸）和28%（鼻拭子；p<0.001）。肺炎链球菌、卡他莫拉菌和流感嗜血杆菌的携带率分别为45%、33%和30%。为实现最佳检测，需要同时采集鼻拭子和口拭子样本。
结论
在健康状态及感冒期间，四分之三的成年人鼻咽部存在细菌病原体。
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