Fairhurst S
Industrial Chemicals Unit, Magdalen House, Stanley Precinct, Bootle, Merseyside L20 3QZ, UK.
Food Chem Toxicol. 2003 Nov;41(11):1453-62. doi: 10.1016/s0278-6915(03)00193-5.
This paper is about industrial chemicals, the manner in which their toxicity is assessed and the use of such assessments in regulatory decision-making. It begins with general points concerning toxicological data availability and hazard identification, then moves on to risk assessment and occupational exposure limits, and finally looks briefly at three specific toxicological issues, asthma, chronic toxic encephalopathy, and "low toxicity" dust effects on the lung, where the science is far from resolved. The overall purpose of the paper is to raise, or perhaps to act as a reminder of a number of issues of particular relevance to industrial chemicals and the occupational setting, and hopefully to prompt further thinking and perhaps some new initiatives directed at the areas in question.
本文围绕工业化学品展开，涉及评估其毒性的方式以及此类评估在监管决策中的应用。文章开篇阐述了毒理学数据可得性及危害识别的一般要点，接着论述风险评估和职业接触限值，最后简要探讨了三个特定的毒理学问题，即哮喘、慢性中毒性脑病以及“低毒性”粉尘对肺部的影响，而这些问题的科学研究尚未定论。本文的总体目的是提出，或者说是提醒人们关注一些与工业化学品及职业环境特别相关的问题，希望能促使人们进一步思考，并针对相关领域采取一些新举措。
