Jones P W, Taylor D M, Williams D R, Finney M, Iorwerth A, Webster D, Harding K G
Chemistry Department, Cardiff University, Wales, UK.
J Wound Care. 2001 Jun;10(6):205-8. doi: 10.12968/jowc.2001.10.6.26084.
A series of wound fluid and blood plasma samples from 20 patients with breast cancer were analysed by Potentiometric Stripping Analysis and computer-aided chemical speciation to quantify the concentrations of the trace elements of copper and zinc in the samples and to investigate the individual species of copper and zinc present. Comparisons were made between total concentrations of copper and zinc in wound fluid, pre-operative blood plasma levels and reference values. A wound fluid model constructed using JESS identified the main copper and zinc species present. It was also used to investigate the effects of a change in pH and changes in the total concentrations of certain components on their predominance. The clinical significance of the research is discussed, together with suggestions for a continuation in the research.
通过电位溶出分析和计算机辅助化学形态分析，对20例乳腺癌患者的一系列伤口渗出液和血浆样本进行分析，以量化样本中铜和锌微量元素的浓度，并研究铜和锌的具体存在形态。对伤口渗出液中铜和锌的总浓度、术前血浆水平和参考值进行了比较。使用JESS构建的伤口渗出液模型确定了主要的铜和锌形态。该模型还用于研究pH值变化和某些成分总浓度变化对其优势形态的影响。讨论了该研究的临床意义以及对后续研究的建议。
