Wang N K, Su C K
Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan, R.O.C.
Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi. 1992 Sep-Oct;33(5):350-6.
In a prospective study on the integrity of the interatrial septum in the neonates, multiple interatrial septal defects or openings with shunting were discovered in nine neonates by means of the color flow mapping technique used in their first week of life among 130 Chinese neonates. Eight of the nine neonates had two openings each, and the remaining one had four openings. Thus a total of 20 openings were found in the 9 neonates. Openings located between the tip of the flap valve and the superior limbus of the foramen ovale were classified as "location A openings" (valve-like openings). Those located at the flap valve itself were classified as "location B openings" (fenestrations). Each of the 9 neonates had one opening at location A, eight of them had another opening at location B; one had three openings at location B. Six of the nine neonates were followed up at age of one month, three months and six months by means of color-flow mapping, with a total of six openings at location A and eight openings at location B. Four out of the six openings of location A and seven out of the eight openings at location B closed spontaneously before the age of six months. In conclusion, seven percent (9/130) of these Chinese neonates have multiple interatrial openings. The openings tend to close spontaneously, regardless of their locations.
在一项关于新生儿房间隔完整性的前瞻性研究中，在中国130名新生儿出生第一周内，通过彩色血流成像技术，在9名新生儿中发现了多个房间隔缺损或分流开口。这9名新生儿中，8名各有两个开口，其余1名有4个开口。因此，9名新生儿中共发现20个开口。位于瓣叶尖端与卵圆孔上缘之间的开口被归类为“A型开口”（瓣膜样开口）。位于瓣叶本身的开口被归类为“B型开口”（筛孔）。9名新生儿中每人在A型位置有一个开口，其中8人在B型位置有另一个开口；1人在B型位置有三个开口。9名新生儿中的6名在1个月、3个月和6个月时通过彩色血流成像进行随访，A型位置共有6个开口，B型位置有8个开口。A型位置的6个开口中有4个以及B型位置的8个开口中有7个在6个月龄前自发闭合。总之，这些中国新生儿中有7%（9/130）存在多个房间隔开口。无论开口位置如何，这些开口都倾向于自发闭合。
