Bartolomucci Alessandro, Sacerdote Paola, Panerai Alberto E, Pederzani Tiziana, Palanza Paola, Parmigiani Stefano
Dipartimento di Biologia Evolutiva e Funzionale, Università di Parma, 43100 Parma, Italy.
J Neuroimmunol. 2003 Aug;141(1-2):58-64. doi: 10.1016/s0165-5728(03)00220-0.
The effect of chronic stress on immune functions is strongly biased by individual factors. Mice were subjected to a new model of chronic psychosocial stress in which four different subcategories of stressed animals may be identified: Resident Dominants (RD), Resident Subordinates (RS), Intruder Dominants (InD), and Intruder Subordinates (InS). After 7 days of stress, mice were immunized with keyhole limpet hemocyanine (KLH). Their immune functions were investigated 14 days later with stress continuing trough. Importantly, RS mice, which are mice losing territory ownership, were the more affected, having lower IgG, proliferation, and IL-2. RD and InD showed lower IgG while InS showed no immune alteration. In conclusion, loss of resources could be a key factor in determining individual vulnerability to stressful events.
慢性应激对免疫功能的影响在很大程度上受到个体因素的影响。小鼠被置于一种新的慢性心理社会应激模型中，在该模型中可以识别出四种不同亚类的应激动物：常驻优势者（RD）、常驻从属者（RS）、入侵者优势者（InD）和入侵者从属者（InS）。应激7天后，用匙孔血蓝蛋白（KLH）对小鼠进行免疫接种。14天后在应激持续的情况下对它们的免疫功能进行研究。重要的是，RS小鼠（即失去领地所有权的小鼠）受影响更大，其IgG、增殖和白细胞介素-2水平较低。RD和InD的IgG水平较低，而InS则未显示出免疫改变。总之，资源丧失可能是决定个体对应激事件易感性的关键因素。
