Avitsur Ronit, Kinsey Steven G, Bidor Kineret, Bailey Michael T, Padgett David A, Sheridan John F
School of Behavioral Sciences, The Academic College of Tel Aviv-Yaffo, Yaffo, Israel.
Psychoneuroendocrinology. 2007 Sep-Nov;32(8-10):1097-105. doi: 10.1016/j.psyneuen.2007.09.005. Epub 2007 Oct 22.
Social stress has long been known to affect physical and psychological health in humans and a variety of animal species. In mice, disruption of the social hierarchy (social disruption, SDR) resulted in significant changes in the phenotype and function of immune cells taken from the spleen. Interestingly, there were considerable individual differences in the development of this splenic response to SDR. Studies have suggested that these individual differences were mediated by behavioral factors such as social hierarchy. To test this hypothesis, social status within cages of male mice was identified before and after SDR. Results showed that in the majority of the cages social order was stable over time. In addition, examination of the association between social status and splenic function showed that the splenic response to SDR in subordinate mice was significantly augmented compared to dominants. This relationship between subordinate social status and the splenic response to social stress was more notable in cages with stable social hierarchies. To sum up, the current study showed a role for socio-behavioral factors in determining the response to stress. This study further demonstrated the complexity of factors playing a role in mediating the physiological response to social stress resulting in considerable individual differences in the response to stress.
长期以来，人们都知道社会压力会影响人类和多种动物的身心健康。在小鼠中，社会等级的破坏（社会扰乱，SDR）会导致从脾脏获取的免疫细胞的表型和功能发生显著变化。有趣的是，脾脏对SDR的这种反应的发展存在相当大的个体差异。研究表明，这些个体差异是由社会等级等行为因素介导的。为了验证这一假设，在SDR前后对雄性小鼠笼内的社会地位进行了确定。结果显示，在大多数笼子中，社会秩序随时间推移是稳定的。此外，对社会地位与脾脏功能之间关联的研究表明，与优势小鼠相比，从属小鼠对SDR的脾脏反应显著增强。在社会等级稳定的笼子中，从属社会地位与脾脏对社会压力的反应之间的这种关系更为显著。总之，当前研究表明社会行为因素在决定对压力的反应中发挥了作用。这项研究进一步证明了在介导对社会压力的生理反应中发挥作用的因素的复杂性，这导致了对压力反应中存在相当大的个体差异。
