van Lingen A, Huijgens P C, Visser F C, Ossenkoppele G J, Hoekstra O S, Martens H J, Huitink H, Herscheid K D, Green M V, Teule G J
Department of Nuclear Medicine, Free University Hospital, Amsterdam, The Netherlands.
Eur J Nucl Med. 1992;19(5):315-21. doi: 10.1007/BF00177052.
Line-source experiments were conducted to assess the performance of a gamma-camera equipped with a specially designed 511-keV collimator for the planar imaging of positron emitters. The results were compared with the camera performance with routinely used collimators and radionuclides (thallium-201, technetium-99m and gallium-67). With positron emitters, scatter contributed less to the widening of the line spread function than with radionuclides emitting lower photon energies. These observations can be explained by the relative deterioration in the discrimination power of the gamma-camera to reject scattered radiation at low energies. Planar 511-keV imaging may provide relevant clinical information, as we showed by fluorodeoxyglucose studies in a patient with a myocardial infarction and in a patient with a malignant lymphoma. It is concluded that positron emitters can be effectively applied for planar imaging with the generally available gamma-cameras. This study implies that radiotracers developed for positron emission tomography may find a place in the practice of conventional nuclear medicine.
进行了线源实验，以评估配备专门设计的511 keV准直器用于正电子发射体平面成像的γ相机的性能。将结果与使用常规准直器和放射性核素（铊-201、锝-99m和镓-67）时的相机性能进行了比较。对于正电子发射体，与发射较低光子能量的放射性核素相比，散射对线扩展函数展宽的贡献较小。这些观察结果可以通过γ相机在低能量下拒绝散射辐射的鉴别能力相对下降来解释。正如我们在一名心肌梗死患者和一名恶性淋巴瘤患者的氟脱氧葡萄糖研究中所表明的，平面511 keV成像可能提供相关的临床信息。得出的结论是，正电子发射体可以有效地应用于普通γ相机的平面成像。这项研究表明，为正电子发射断层扫描开发的放射性示踪剂可能在传统核医学实践中占有一席之地。
