Paul R
J Nucl Med. 1987 Mar;28(3):288-92.
Patients with lymphomas are conventionally imaged with [67Ga]citrate for tumor detection and determination of dissemination. Fluorine-18-2-fluoro-2-deoxy-D-glucose [( 18F]FDG) is a radiopharmaceutical that accumulates into tissues where glucose utilization is enhanced, such as tumors. Six cancer patients (five non-Hodgkin's lymphomas, one endodermal retroperitoneal sinus carcinoma) were imaged with [18F]FDG and [67Ga]citrate whole-body scintigraphies in order to compare the sensitivities of these two tumor imaging radiopharmaceuticals. Among the five untreated lymphoma patients, two 67Ga scans and four [18F]FDG scans were positive; in the patient with the retroperitoneal carcinoma who had a positive [18F]FDG scan before treatment, both scans were negative after treatment. Fluorine-18 FDG may be a more sensitive tumor-detecting radiopharmaceutical for non-Hodgkin's lymphoma than [67Ga]citrate.
淋巴瘤患者通常采用[67Ga]枸橼酸盐进行成像，以检测肿瘤并确定其播散情况。氟-18-2-氟-2-脱氧-D-葡萄糖[（18F）FDG]是一种放射性药物，可在葡萄糖利用增强的组织（如肿瘤）中蓄积。对6例癌症患者（5例非霍奇金淋巴瘤、1例腹膜后内胚层窦癌）进行了[18F]FDG和[67Ga]枸橼酸盐全身闪烁扫描，以比较这两种肿瘤成像放射性药物的敏感性。在5例未经治疗的淋巴瘤患者中，2例67Ga扫描阳性，4例[18F]FDG扫描阳性；在1例腹膜后癌患者中，治疗前[18F]FDG扫描阳性，治疗后两种扫描均为阴性。对于非霍奇金淋巴瘤，氟-18 FDG可能是一种比[67Ga]枸橼酸盐更敏感的肿瘤检测放射性药物。
