低温对大鼠内毒素诱导性休克死亡率及炎症反应的影响。
Effects of hypothermia on mortality and inflammatory responses to endotoxin-induced shock in rats.
作者信息
Taniguchi Takumi, Kanakura Hiroko, Takemoto Yasuhiro, Yamamoto Ken
机构信息
Department of Emergency and Critical Care Medicine, Graduate School of Medical Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8641, Japan.
出版信息
Clin Diagn Lab Immunol. 2003 Sep;10(5):940-3. doi: 10.1128/cdli.10.5.940-943.2003.
Abstract
We studied the effects of hypothermia on mortality rate, concentrations of tumor necrosis factor alpha and interleukin 6 in plasma, and the end products of nitric oxide (NO) in endotoxemia. It was found that moderate and mild hypothermia improved the mortality rate and attenuated cytokine responses and the elevation of the end products of NO after endotoxin injection and that these beneficial effects were similar for moderate and mild hypothermia.
摘要
我们研究了低温对内毒素血症死亡率、血浆中肿瘤坏死因子α和白细胞介素6浓度以及一氧化氮（NO）终产物的影响。结果发现，中度和轻度低温可提高死亡率，并减轻细胞因子反应以及内毒素注射后NO终产物的升高，且中度和轻度低温的这些有益作用相似。
相似文献
1
Effects of hypothermia on mortality and inflammatory responses to endotoxin-induced shock in rats.低温对大鼠内毒素诱导性休克死亡率及炎症反应的影响。
Clin Diagn Lab Immunol. 2003 Sep;10(5):940-3. doi: 10.1128/cdli.10.5.940-943.2003.
2
The antiinflammatory effects of propofol in endotoxemic rats during moderate and mild hypothermia.异丙酚在中度和轻度低温期间对内毒素血症大鼠的抗炎作用。
J Anesth. 2007;21(3):354-60. doi: 10.1007/s00540-007-0533-y. Epub 2007 Aug 1.
3
The antiinflammatory effects of ketamine in endotoxemic rats during moderate and mild hypothermia.
Anesth Analg. 2004 Apr;98(4):1114-1120. doi: 10.1213/01.ANE.0000100740.07331.A2.
4
Effects of dexmedetomidine on mortality rate and inflammatory responses to endotoxin-induced shock in rats.右美托咪定对大鼠内毒素诱导性休克死亡率及炎症反应的影响。
Crit Care Med. 2004 Jun;32(6):1322-6. doi: 10.1097/01.ccm.0000128579.84228.2a.
5
Ketamine inhibits endotoxin-induced shock in rats.氯胺酮可抑制大鼠内毒素诱导的休克。
Anesthesiology. 2001 Oct;95(4):928-32. doi: 10.1097/00000542-200110000-00022.
6
Dose- and time-related effects of dexmedetomidine on mortality and inflammatory responses to endotoxin-induced shock in rats.右美托咪定对大鼠内毒素诱导性休克死亡率及炎症反应的剂量和时间相关效应
J Anesth. 2008;22(3):221-8. doi: 10.1007/s00540-008-0611-9. Epub 2008 Aug 7.
7
Molecular hydrogen potentiates hypothermia and prevents hypotension and fever in LPS-induced systemic inflammation.分子氢增强了低温治疗的效果，并预防了 LPS 诱导的全身炎症中的低血压和发热。
Brain Behav Immun. 2019 Jan;75:119-128. doi: 10.1016/j.bbi.2018.09.027. Epub 2018 Sep 24.
8
Effects of posttreatment with propofol on mortality and cytokine responses to endotoxin-induced shock in rats.
Crit Care Med. 2002 Apr;30(4):904-7. doi: 10.1097/00003246-200204000-00032.
9
Effects of acute low-dose ethanol on inflammatory reactions to endotoxin-induced shock in rats.急性低剂量乙醇对大鼠内毒素诱导性休克炎症反应的影响。
J Toxicol Sci. 2012;37(3):649-54. doi: 10.2131/jts.37.649.
10
Nitrite/nitrate oxide (NOx) and cytokine levels in patients with septic shock.脓毒性休克患者的亚硝酸盐/硝酸盐氧化物（NOx）和细胞因子水平
Res Commun Mol Pathol Pharmacol. 1996 Mar;91(3):347-56.
引用本文的文献
1
Intensive fever control using a therapeutic normothermia protocol in patients with febrile early septic shock: A randomized feasibility trial and exploration of the immunomodulatory effects.采用治疗性正常体温方案对发热性早期脓毒性休克患者进行强化体温控制：一项随机可行性试验及免疫调节作用探索。
SAGE Open Med. 2020 Jun 3;8:2050312120928732. doi: 10.1177/2050312120928732. eCollection 2020.
2
Expression profiling of microRNAs in lipopolysaccharide-induced acute lung injury after hypothermia treatment.低温治疗后脂多糖诱导的急性肺损伤中微小RNA的表达谱分析
Mol Cell Toxicol. 2016;12(3):243-253. doi: 10.1007/s13273-016-0029-7. Epub 2016 Oct 7.
3
Partial liquid ventilation-induced mild hypothermia improves the lung function and alleviates the inflammatory response during acute respiratory distress syndrome in canines.部分液体通气诱导的亚低温改善犬急性呼吸窘迫综合征时的肺功能并减轻炎症反应。
Biomed Pharmacother. 2019 Oct;118:109344. doi: 10.1016/j.biopha.2019.109344. Epub 2019 Aug 14.
4
Effects of Target Temperature Management on the Outcome of Septic Patients with Fever.目标温度管理对发热脓毒症患者结局的影响。
Biomed Res Int. 2017;2017:3906032. doi: 10.1155/2017/3906032. Epub 2017 Nov 12.
5
Cardiac arrest patients have an impaired immune response, which is not influenced by induced hypothermia.心脏骤停患者存在免疫反应受损的情况，这种情况不受诱导低温的影响。
Crit Care. 2014 Jul 30;18(4):R162. doi: 10.1186/cc14002.
6
Hypothermia attenuates NO production in anesthetized rats with endotoxemia.体温过低会减弱内毒素血症麻醉大鼠体内一氧化氮的生成。
Naunyn Schmiedebergs Arch Pharmacol. 2014 Jul;387(7):659-65. doi: 10.1007/s00210-014-0977-1. Epub 2014 Apr 11.
7
Hypothermia induced by adenosine 5'-monophosphate attenuates acute lung injury induced by LPS in rats.腺嘌呤核苷 5′-单磷酸诱导的低温减轻脂多糖诱导的大鼠急性肺损伤。
Mediators Inflamm. 2012;2012:459617. doi: 10.1155/2012/459617. Epub 2012 Sep 13.
8
Under-humidification and over-humidification during moderate induced hypothermia with usual devices.使用常规设备进行中度亚低温治疗期间的加湿不足和加湿过度。
Intensive Care Med. 2006 Jul;32(7):1014-21. doi: 10.1007/s00134-006-0192-8. Epub 2006 May 23.
本文引用的文献
1
Moderate hypothermia delays proinflammatory cytokine production of human peripheral blood mononuclear cells.
Crit Care Med. 2002 Jul;30(7):1499-502. doi: 10.1097/00003246-200207000-00017.
2
Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia.对院外心脏骤停昏迷幸存者进行亚低温治疗。
N Engl J Med. 2002 Feb 21;346(8):557-63. doi: 10.1056/NEJMoa003289.
3
Ketamine inhibits endotoxin-induced shock in rats.氯胺酮可抑制大鼠内毒素诱导的休克。
Anesthesiology. 2001 Oct;95(4):928-32. doi: 10.1097/00000542-200110000-00022.
4
Hypothermia induces T-cell production of immunosuppressive cytokines.体温过低会诱导T细胞产生免疫抑制细胞因子。
J Surg Res. 2001 Oct;100(2):150-3. doi: 10.1006/jsre.2001.6230.
5
Moderate hypothermia during cardiopulmonary bypass reduces myocardial cell damage and myocardial cell death related to cardiac surgery.
J Am Coll Cardiol. 2001 Oct;38(4):1216-23. doi: 10.1016/s0735-1097(01)01469-3.
6
Moderate hypothermia blunts the inflammatory response and reduces organ injury after acute haemorrhage.
Acta Anaesthesiol Scand. 2001 Sep;45(8):994-1001. doi: 10.1034/j.1399-6576.2001.450812.x.
7
Influence of temperature during cardiopulmonary bypass on leukocyte activation, cytokine balance, and post-operative organ damage.体外循环期间温度对白细胞活化、细胞因子平衡及术后器官损伤的影响。
Shock. 2001 May;15(5):372-7. doi: 10.1097/00024382-200115050-00007.
8
Hypothermia and cytokines in septic shock. Norasept II Study Investigators. North American study of the safety and efficacy of murine monoclonal antibody to tumor necrosis factor for the treatment of septic shock.脓毒性休克中的体温过低与细胞因子。诺拉塞普II研究调查组。北美关于鼠抗肿瘤坏死因子单克隆抗体治疗脓毒性休克安全性和有效性的研究。
Intensive Care Med. 2000 Jun;26(6):716-21. doi: 10.1007/s001340051237.
9
Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats.丙泊酚对大鼠内毒素血症血流动力学及炎症反应的影响。
Crit Care Med. 2000 Apr;28(4):1101-6. doi: 10.1097/00003246-200004000-00032.
10
Effects of ibuprofen on the physiology and survival of hypothermic sepsis. Ibuprofen in Sepsis Study Group.布洛芬对低温脓毒症生理机能及存活率的影响。脓毒症布洛芬研究小组
Crit Care Med. 1999 Apr;27(4):699-707. doi: 10.1097/00003246-199904000-00020.
Zotero 插件