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本文引用的文献

1
Moderate hypothermia delays proinflammatory cytokine production of human peripheral blood mononuclear cells.
Crit Care Med. 2002 Jul;30(7):1499-502. doi: 10.1097/00003246-200207000-00017.
2
Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia.对院外心脏骤停昏迷幸存者进行亚低温治疗。
N Engl J Med. 2002 Feb 21;346(8):557-63. doi: 10.1056/NEJMoa003289.
3
Ketamine inhibits endotoxin-induced shock in rats.氯胺酮可抑制大鼠内毒素诱导的休克。
Anesthesiology. 2001 Oct;95(4):928-32. doi: 10.1097/00000542-200110000-00022.
4
Hypothermia induces T-cell production of immunosuppressive cytokines.体温过低会诱导T细胞产生免疫抑制细胞因子。
J Surg Res. 2001 Oct;100(2):150-3. doi: 10.1006/jsre.2001.6230.
5
Moderate hypothermia during cardiopulmonary bypass reduces myocardial cell damage and myocardial cell death related to cardiac surgery.
J Am Coll Cardiol. 2001 Oct;38(4):1216-23. doi: 10.1016/s0735-1097(01)01469-3.
6
Moderate hypothermia blunts the inflammatory response and reduces organ injury after acute haemorrhage.
Acta Anaesthesiol Scand. 2001 Sep;45(8):994-1001. doi: 10.1034/j.1399-6576.2001.450812.x.
7
Influence of temperature during cardiopulmonary bypass on leukocyte activation, cytokine balance, and post-operative organ damage.体外循环期间温度对白细胞活化、细胞因子平衡及术后器官损伤的影响。
Shock. 2001 May;15(5):372-7. doi: 10.1097/00024382-200115050-00007.
8
Hypothermia and cytokines in septic shock. Norasept II Study Investigators. North American study of the safety and efficacy of murine monoclonal antibody to tumor necrosis factor for the treatment of septic shock.脓毒性休克中的体温过低与细胞因子。诺拉塞普II研究调查组。北美关于鼠抗肿瘤坏死因子单克隆抗体治疗脓毒性休克安全性和有效性的研究。
Intensive Care Med. 2000 Jun;26(6):716-21. doi: 10.1007/s001340051237.
9
Effects of propofol on hemodynamic and inflammatory responses to endotoxemia in rats.丙泊酚对大鼠内毒素血症血流动力学及炎症反应的影响。
Crit Care Med. 2000 Apr;28(4):1101-6. doi: 10.1097/00003246-200004000-00032.
10
Effects of ibuprofen on the physiology and survival of hypothermic sepsis. Ibuprofen in Sepsis Study Group.布洛芬对低温脓毒症生理机能及存活率的影响。脓毒症布洛芬研究小组
Crit Care Med. 1999 Apr;27(4):699-707. doi: 10.1097/00003246-199904000-00020.

低温对大鼠内毒素诱导性休克死亡率及炎症反应的影响。

Effects of hypothermia on mortality and inflammatory responses to endotoxin-induced shock in rats.

作者信息

Taniguchi Takumi, Kanakura Hiroko, Takemoto Yasuhiro, Yamamoto Ken

机构信息

Department of Emergency and Critical Care Medicine, Graduate School of Medical Science, Kanazawa University Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8641, Japan.

出版信息

Clin Diagn Lab Immunol. 2003 Sep;10(5):940-3. doi: 10.1128/cdli.10.5.940-943.2003.

DOI:10.1128/cdli.10.5.940-943.2003
PMID:12965930
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC193915/
Abstract

We studied the effects of hypothermia on mortality rate, concentrations of tumor necrosis factor alpha and interleukin 6 in plasma, and the end products of nitric oxide (NO) in endotoxemia. It was found that moderate and mild hypothermia improved the mortality rate and attenuated cytokine responses and the elevation of the end products of NO after endotoxin injection and that these beneficial effects were similar for moderate and mild hypothermia.

摘要

我们研究了低温对内毒素血症死亡率、血浆中肿瘤坏死因子α和白细胞介素6浓度以及一氧化氮（NO）终产物的影响。结果发现，中度和轻度低温可提高死亡率，并减轻细胞因子反应以及内毒素注射后NO终产物的升高，且中度和轻度低温的这些有益作用相似。