Kantaputra Piranit, Tanpaiboon Pranoot
Department of Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai 50200, Thailand.
Am J Med Genet A. 2003 Oct 15;122A(3):274-7. doi: 10.1002/ajmg.a.20269.
We report a Thai girl who had aglossia, micrognathia, microsomia, collapse of mandibular arch, persistence of buccopharyngeal membrane, microcephaly, and mild developmental delay. Thyroid function tests indicated that she had subclinical hypothyroidism. Thyroid scan revealed normal uptake of the whole thyroid gland. Tongue morphogenesis is integrally linked to the normal development of thyroid gland, and abnormal tongue morphogenesis could potentially result in a functional thyroid disorder. We propose that micrognathia, microsomia, congenital absence of mandibular incisors, and collapse of the mandibular arch are the result of abnormal tongue development.
我们报告了一名泰国女孩，她患有无舌症、小颌畸形、小身材、下颌弓塌陷、颊咽膜持续存在、小头畸形和轻度发育迟缓。甲状腺功能测试表明她患有亚临床甲状腺功能减退症。甲状腺扫描显示整个甲状腺摄取正常。舌形态发生与甲状腺的正常发育密切相关，异常的舌形态发生可能会导致功能性甲状腺疾病。我们认为小颌畸形、小身材、先天性下颌切牙缺失和下颌弓塌陷是舌发育异常的结果。
