Senanayake Sanjaya, Kelly John, Lloyd Andrew, Waliuzzaman Zubair, Goldstein David, Rawlinson William
Department of Infectious Diseases, Prince of Wales Hospital, Barker Street, Randwick, New South Wales 2031, Australia.
J Med Virol. 2003 Nov;71(3):399-403. doi: 10.1002/jmv.10500.
A patient negative for human immunodeficiency virus (HIV) developed multicentric Castleman's disease (MCD) and Kaposi's sarcoma (KS) associated with active human herpesvirus 8 (HHV-8) infection. He was treated with sequential antiviral therapy, chemotherapy, and corticosteroids. HHV-8 levels were monitored throughout the course of the patient's illness, and were found to rise on relapse. No consistent change in HHV-8 levels was found with antiviral therapy. We demonstrate that in this patient antiviral therapy was clinically ineffective, and did not alter HHV-8 levels, but that corticosteroid and combination chemotherapy led to clinical improvement. Despite the implication of HHV-8 as a cause of MCD, few studies have correlated HHV-8 levels with clinical response.
一名人类免疫缺陷病毒（HIV）检测呈阴性的患者患上了多中心Castleman病（MCD）和与活跃的人类疱疹病毒8型（HHV-8）感染相关的卡波西肉瘤（KS）。他接受了序贯抗病毒治疗、化疗和皮质类固醇治疗。在患者整个病程中监测HHV-8水平，发现复发时其水平升高。抗病毒治疗未发现HHV-8水平有一致变化。我们证明，在该患者中抗病毒治疗在临床上无效，且未改变HHV-8水平，但皮质类固醇和联合化疗导致了临床改善。尽管HHV-8被认为是MCD的病因之一，但很少有研究将HHV-8水平与临床反应相关联。
