Simonart T, Noel J C, De Dobbeleer G, Parent D, Van Vooren J P, De Clercq E, Snoeck R
Department of Dermatology, Erasme University Hospital, Brussels, Belgium.
J Med Virol. 1998 Jul;55(3):215-8.
The effect of intralesional injections of cidofovir, a nucleotide analog with potent in vitro activity against human herpesvirus 8 (HHV-8), was studied in vivo in an HIV-negative patient with classical Kaposi's sarcoma (KS). After five weekly injections of the drug, no clinical, histological, immunohistological, or virological changes could be detected in comparison with saline-injected lesions. These findings suggest that, once the KS tumor has developed, active viral replication is no longer involved in the pathogenesis of the disease. Alternative hypotheses are that HHV-8 replication in blood-borne cells may foster growth of spindle cells in the skin, or that blocking HHV-8 may not affect existing lesions but may prevent new lesions from developing.
在一名患有经典卡波西肉瘤（KS）的HIV阴性患者体内，研究了病灶内注射西多福韦（一种对人疱疹病毒8型（HHV - 8）具有强大体外活性的核苷酸类似物）的效果。与注射生理盐水的病灶相比，在每周注射该药物五次后，未检测到临床、组织学、免疫组织学或病毒学变化。这些发现表明，一旦KS肿瘤形成，病毒的活跃复制不再参与该疾病的发病机制。其他假说是，HHV - 8在血源性细胞中的复制可能促进皮肤中梭形细胞的生长，或者阻断HHV - 8可能不会影响现有病灶，但可能会阻止新病灶的形成。
