Choi Byeong-Sun, Kim Okjin, Park Mi Sun, Kim Ki Soo, Jeong Jeongmi Kim, Lee Joo-Shil
Center for AIDS Research, Department of Virology, National Institute of Health, #5 Nokbun-dong, Eunpyung-gu, Seoul, Korea 122-701, Republic of Korea.
J Med Virol. 2003 Nov;71(3):440-5. doi: 10.1002/jmv.10498.
Because of the diversity in human papillomavirus (HPV) distribution, according to the population and region, detailed investigations of HPV genotypes are important in designing more effective HPV vaccines for any given country. HPV DNA oligonucleotide microarray was used to investigate the distribution of HPV genotypes among commercial sex workers. The prevalence of HPV in Korean commercial sex workers was 47%, with HPV-16 and HPV-51 as the dominant genotypes. HPV subtypes in 148 commercial sex workers comprised 70 with one genotype, 42 with two genotypes, 17 with three genotypes, and 19 with four or more genotypes. HPV-40, the most dominant low-risk genotype, was not detected in single-infection commercial sex workers. All women with multiple infections of low-risk genotypes had the HPV-40 genotype. This molecular epidemiological study of genital HPV will be useful for the development of a favorable strategy to prevent the spread of this potentially serious infection.
由于人乳头瘤病毒（HPV）分布存在多样性，根据人群和地区不同，针对任何特定国家设计更有效的HPV疫苗时，详细调查HPV基因型非常重要。采用HPV DNA寡核苷酸微阵列研究性工作者中HPV基因型的分布情况。韩国性工作者中HPV的感染率为47%，其中HPV-16和HPV-51为主要基因型。148名性工作者的HPV亚型中，70人感染一种基因型，42人感染两种基因型，17人感染三种基因型，19人感染四种或更多基因型。在单一感染的性工作者中未检测到最主要的低风险基因型HPV-40。所有低风险基因型多重感染的女性均有HPV-40基因型。这项关于生殖道HPV的分子流行病学研究将有助于制定有利策略，以预防这种潜在严重感染的传播。
