麦角生物碱的开环C/D环类似物。通过分子内Heck反应和关环复分解反应合成。
seco-C/D ring analogues of ergot alkaloids. Synthesis via intramolecular Heck and ring-closing metathesis reactions.
作者信息
Kalinin Alexey V, Chauder Brian A, Rakhit Suman, Snieckus Victor
机构信息
Department of Chemistry, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1.
出版信息
Org Lett. 2003 Sep 18;5(19):3519-21. doi: 10.1021/ol035398t.
PMID:12967314
Abstract
[reaction: see text] Intramolecular Heck and ring-closing metathesis reactions on key intermediates 10 and 15, respectively, provide efficient entries into seco-C/D ring analogues of Ergot alkaloids 12 and 16, compounds of potential synthetic and biological interest.
摘要
[反应：见正文] 分别在关键中间体10和15上进行分子内Heck反应和关环复分解反应，为高效合成麦角生物碱12和16的开环C/D环类似物提供了途径，这些化合物具有潜在的合成和生物学研究价值。
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