血管紧张素转换酶ID多态性与中国男性最大摄氧量之间的关系。
Relationship between angiotensin-converting enzyme ID polymorphism and VO(2max) of Chinese males.
作者信息
Zhao Bin, Moochhala Shabbir M, Tham Su yin, Lu Jia, Chia Michael, Byrne Christopher, Hu Qichen, Lee Lionel K H
机构信息
Defence Science and Technology Agency, MD2, National University of Singapore, 117 597 Singapore, Singapore.
出版信息
Life Sci. 2003 Oct 3;73(20):2625-30. doi: 10.1016/s0024-3205(03)00608-8.
Several studies have shown that the angiotensin-converting enzyme (ACE) I allele is associated with enhanced physical performance. We investigated whether this phenomenon is observed in a cohort of 67 Chinese men in Singapore. Angiotensin-converting enzyme ID polymorphism was typed with PCR method and maximal oxygen uptake (VO(2max)) of the DD, ID, and II genotypes was compared. Analysis of covariance revealed that VO(2max) was significantly higher (p<0.05) for the DD genotype (57.86 +/- 3.5 ml.kg.(-1)min(-1)) versus the ID (50.58 +/- 1.80 ml.kg.(-1)min(-1)) or II (50.48 +/- 1.58 ml.kg.(-1) min(-1)) genotype. Our findings suggest that the ACE DD genotype in young adult Chinese males is associated with higher levels of VO(2max).
多项研究表明，血管紧张素转换酶（ACE）I等位基因与体能增强有关。我们调查了在新加坡的67名中国男性队列中是否观察到这种现象。采用PCR方法对血管紧张素转换酶ID多态性进行分型，并比较DD、ID和II基因型的最大摄氧量（VO₂max）。协方差分析显示，DD基因型（57.86±3.5 ml·kg⁻¹·min⁻¹）的VO₂max显著高于ID基因型（50.58±1.80 ml·kg⁻¹·min⁻¹）或II基因型（50.48±1.58 ml·kg⁻¹·min⁻¹）（p<0.05）。我们的研究结果表明，年轻成年中国男性中的ACE DD基因型与较高水平的VO₂max相关。
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