Jope Richard S
Department of Psychiatry and Behavioral Neurobiology, 1720 7th Ave South, Sparks Center 1057, University of Alabama at Birmingham, Birmingham, AL 35294-0017, USA.
Trends Pharmacol Sci. 2003 Sep;24(9):441-3. doi: 10.1016/S0165-6147(03)00206-2.
The intrigue of lithium, the simplest drug in the modern pharmacopoeia, extends from its complex actions in cells to its therapeutic effects as a mood stabilizer. New surprises from studies of glycogen synthase kinase 3 (GSK-3) show that lithium reduces GSK-3 activity in two ways, both directly and by increasing the inhibitory phosphorylation of GSK-3. These dual effects can act in concert to magnify the influence of lithium on crucial GSK-3-regulated functions (gene expression, cell structure and survival).
锂，现代药典中最简单的药物，其奥秘从它在细胞内的复杂作用延伸到作为情绪稳定剂的治疗效果。糖原合酶激酶3（GSK-3）研究的新惊喜表明，锂通过两种方式降低GSK-3活性，既直接作用，也通过增加GSK-3的抑制性磷酸化来实现。这些双重作用可以协同发挥，放大锂对关键的GSK-3调节功能（基因表达、细胞结构和存活）的影响。
