Abe Gabriela L, Xiao Linghao, Sasaki Jun-Ichi, Sakai Hirohiko, Kitagawa Haruaki, Kohno Tomoki, Funayama Naoya, Imazato Satoshi
Joint Research Laboratory of Advanced Functional Materials Science, Osaka University Graduate School of Dentistry, Suita 565-0871, Japan.
Department of Dental Biomaterials, Osaka University Graduate School of Dentistry, Suita 565-0871, Japan.
ACS Appl Bio Mater. 2025 Jun 16;8(6):4756-4765. doi: 10.1021/acsabm.5c00128. Epub 2025 May 31.
Delay in the resolution of inflammation has disastrous implications for tissue regeneration, but local anti-inflammatory signals could accelerate this process. To test this, phosphate-based bioactive glasses were fabricated to release lithium, an anti-inflammatory ion, at a range of ionic concentrations. Lithium release was contingent on the aluminum molar ratio within the glass formulation. Glasses that released lithium faster exerted greater anti-inflammatory effects on activated macrophages. These effects resulted from the inhibition of GSK3β activity and the promotion of CD206 expression. This study demonstrates the therapeutic potential of anti-inflammatory phosphate glasses in resolving inflammation in the regenerative environment.
炎症消退延迟对组织再生具有灾难性影响，但局部抗炎信号可加速这一过程。为了验证这一点，制备了基于磷酸盐的生物活性玻璃，以在一系列离子浓度下释放抗炎离子锂。锂的释放取决于玻璃配方中的铝摩尔比。锂释放较快的玻璃对活化的巨噬细胞具有更强的抗炎作用。这些作用源于对GSK3β活性的抑制和CD206表达的促进。本研究证明了抗炎磷酸盐玻璃在再生环境中解决炎症的治疗潜力。
