Arpinati Mario, Chirumbolo Gabriella, Urbini Benedetta, Perrone Giulia, Rondelli Damiano, Anasetti Claudio
Centro di Ricerca sull'Immunologia dei Trapianti, Istituto di Ematologia e Oncologia Medica Seragnoli, Universita' di Bologna, Via Massarenti 9, Bologna 40138, Italy.
Transpl Immunol. 2003 Jul-Sep;11(3-4):345-56. doi: 10.1016/S0966-3274(03)00055-8.
Dendritic cells (DC) may play an important role in the pathogenesis of alloimmune reactions, such as graft-vs.-host disease after allogeneic hematopoietic stem cell transplantation (HSCT). In humans, two types of DC-myeloid DC (mDC) and plasmacytoid DC (pDC) have been characterized and have distinct origins and functions. The data obtained from studies in vitro suggest that pDC are involved in the regulation of immunity, including the induction and maintenance of tolerance, as well as in the defence against viruses. The authors will review all the evidence currently available from reports exploring the role of pDC in clinical allogeneic HSCT.
树突状细胞（DC）可能在同种免疫反应的发病机制中发挥重要作用，例如异基因造血干细胞移植（HSCT）后的移植物抗宿主病。在人类中，已鉴定出两种类型的DC——髓样DC（mDC）和浆细胞样DC（pDC），它们具有不同的起源和功能。体外研究获得的数据表明，pDC参与免疫调节，包括诱导和维持耐受性，以及抵御病毒。作者将综述目前所有关于探索pDC在临床异基因HSCT中作用的报告所提供的证据。
