Laboratório de Imunologia Tumoral, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, RJ, Brazil.
J Immunol Res. 2016;2016:4753607. doi: 10.1155/2016/4753607. Epub 2016 Mar 21.
Dendritic cells are antigen-presenting cells capable of either activating the immune response or inducing and maintaining immune tolerance. They do this by integrating stimuli from the environment and changing their functional status as a result of plasticity. The modifications suffered by these cells have consequences in the way the organism may respond. In the present work two opposing situations known to affect dendritic cells are analyzed: tumor growth, leading to a microenvironment that favors the induction of a tolerogenic profile, and organ transplantation, which leads to a proinflammatory profile. Lessons learned from these situations may help to understand the mechanisms of modulation resulting not only from the above circumstances, but also from other pathologies.
树突状细胞是抗原呈递细胞，能够激活免疫反应或诱导和维持免疫耐受。它们通过整合来自环境的刺激，并由于可塑性而改变其功能状态来实现这一点。这些细胞所经历的修饰会影响生物体可能的反应方式。在本工作中，分析了两种已知会影响树突状细胞的相反情况：肿瘤生长导致有利于诱导耐受表型的微环境，以及器官移植导致促炎表型。从这些情况中获得的经验教训可能有助于理解不仅来自上述情况，而且还来自其他病理学的调节机制。
