School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan.
Planta Med. 2012 Oct;78(15):1636-8. doi: 10.1055/s-0032-1315208. Epub 2012 Aug 13.
This study examined the anti-herpes simplex virus type I activity of the major constituents of several essential oils. Plaque reduction assays were performed to evaluate anti-herpes simplex virus type I activity. Thymol and carvacrol both possessed significant antiviral activity with an IC₅₀ of 7 µM, and herpes simplex virus type I was 90 % inactivated within 1 hr. The mode of antiviral action was shown to affect the virion directly. Evidence was also observed by electron microscopy. Evaluation of the structural requirements for antiviral activity of thymol-related monoterpenoids revealed that aliphatic side chains had a minor effect, while a hydrophilic group on the benzene ring was sufficient for activity. Our results suggest that thymol and carvacrol are potential candidates for topical therapeutic application to reduce herpes simplex virus transmission.
本研究考察了几种精油的主要成分对单纯疱疹病毒 I 型的抗病毒活性。通过噬斑减少法评估抗单纯疱疹病毒 I 型活性。百里香酚和香芹酚均具有显著的抗病毒活性，IC₅₀值为 7 μM，1 小时内可使单纯疱疹病毒 I 型灭活 90%。抗病毒作用方式表明其直接作用于病毒粒子。电子显微镜观察也提供了证据。对与百里香酚相关的单萜类化合物的抗病毒活性的结构要求进行评估，结果表明脂肪族侧链的影响较小，而苯环上的亲水基团则足以发挥活性。我们的研究结果表明，百里香酚和香芹酚是减少单纯疱疹病毒传播的局部治疗应用的潜在候选药物。
