Brtková A
Výskumný ústav výzivy l'udu v Bratislave, CSFR.
Bratisl Lek Listy. 1992 Dec;93(12):629-32.
The role of selenium concerning its biological effects particularly in relation to cardiovascular and tumor diseases has been in the focus of intensive studies. Selenium is a constituent part of the enzyme glutathion peroxidase (E.C.1.11.1.9) which catalyzes the conversion of hydrogen peroxide and organic hydroperoxides into water and corresponding alcohols. A review of epidemiological studies is presented focusing predominantly on countries where a low concentration of selenium in blood serum was found. The role of selenium in the etiology of cardiovascular diseases may probably be accounted for by its protective effect as it prevents platelet aggregation and protects the arterial endothelium from being damaged by lipid peroxides. The results of experimental studies, carried out in research institutes in many parts of the world, suggest that coordinated supplementation of food with selenium may reduce the risk of cancer and moreover, the effect of selenium can be modified by other dietary factors, such as vitamin A and E. (Fig. 2, Ref. 29.)
硒在生物学效应方面的作用，尤其是与心血管疾病和肿瘤疾病相关的作用，一直是深入研究的重点。硒是谷胱甘肽过氧化物酶（E.C.1.11.1.9）的组成部分，该酶催化过氧化氢和有机氢过氧化物转化为水和相应的醇。本文对流行病学研究进行了综述，主要聚焦于血清硒浓度较低的国家。硒在心血管疾病病因学中的作用可能归因于其保护作用，因为它可防止血小板聚集，并保护动脉内皮免受脂质过氧化物的损伤。世界各地研究机构进行的实验研究结果表明，食物中协同补充硒可能降低患癌风险，此外，硒的作用可被其他饮食因素（如维生素A和E）改变。（图2，参考文献29。）
