Liao Xiao-Long, Wang Zhong-Hua, Liang Xiu-Na, Liang Jun, Wei Xue-Biao, Wang Shou-Hong, Guo Wei-Xin
Department of Critical Care Medicine, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, People's Republic of China.
Diabetes Metab Syndr Obes. 2020 Dec 3;13:4755-4761. doi: 10.2147/DMSO.S284120. eCollection 2020.
The relationship between circulating selenium and diabetes mellitus (DM) remains inconsistent. Therefore, the relationship between circulating selenium and DM was investigated in the present study.
All participants (aged ≥18 years) were included from the National Health and Nutrition Examination Survey (NHANES) 1999-2006. Selenium concentrations from the fasting serum samples were determined using inductively coupled mass spectrometry, then grouped into quartiles. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated by using multivariate logistic regression analysis and the results were stratified by age and sex.
A total of 2,903 (61.9±13.7 years old) participants (49.3% males) were enrolled, and 580 (19.97%) of them had DM. The mean levels of selenium were 136.4±19.6 µg/L. Patients with DM (138.76±20.02 vs 135.88±19.44, =0.002) had higher selenium levels compared to those without DM. The OR for DM was 1.12 (95% CI=1.01-1.24; =0.0270) for each 10 µg/L increment in selenium, and subjects in the highest quartile of selenium levels (>147.00 uµg/L) had 2.82 (95% CI=1.55-5.11; =0.0007) times higher risk of DM compared to the lowest quartile of selenium levels. Subgroup analysis showed that selenium was independently associated with DM only in female aged <65 years.
Circulating selenium levels were positively associated with the odds of DM, but difference in sex and age.
循环硒与糖尿病（DM）之间的关系仍不一致。因此，本研究对循环硒与DM之间的关系进行了调查。
所有参与者（年龄≥18岁）均来自1999 - 2006年美国国家健康与营养检查调查（NHANES）。使用电感耦合质谱法测定空腹血清样本中的硒浓度，然后分为四分位数。通过多变量逻辑回归分析估计比值比（OR）和95%置信区间（CI），结果按年龄和性别分层。
共纳入2903名参与者（年龄61.9±13.7岁）（男性占49.3%），其中580人（19.97%）患有DM。硒的平均水平为136.4±19.6μg/L。与未患DM的患者相比，DM患者的硒水平更高（138.76±20.02 vs 135.88±19.44，P = 0.002）。硒每增加10μg/L，DM的OR为1.12（95%CI = 1.01 - 1.24；P = 0.0270），硒水平处于最高四分位数（>147.00μg/L）的受试者患DM的风险是硒水平最低四分位数受试者的2.82倍（95%CI = 1.55 - 5.11；P = 0.0007）。亚组分析表明，仅在年龄<65岁的女性中，硒与DM独立相关。
循环硒水平与DM的患病几率呈正相关，但存在性别和年龄差异。
