Marcos I S, Pedrero A B, Sexmero M J, Diez D, Basabe P, García N, Moro R F, Broughton H B, Mollinedo F, Urones J G
Departamento de Química Orgánica, Facultad de Ciencias Químicas, Universidad de Salamanca, Plaza de los Caídos 1-5, 37008 Salamanca, Spain.
J Org Chem. 2003 Sep 19;68(19):7496-504. doi: 10.1021/jo034663l.
The bioactive sesterterpenoid gamma-hydroxybutenolides 15,18-bisepi-ent-Cladocoran A and B, 1 and 2, and 15-epi-ent-Cladocoran A and B, 57 and 55, were synthesized from ent-halimic acid. The synthesized sesterterpenolids 2, 55, 57, and 59 inhibited cellular proliferation (IC(50) congruent with 2 micro M) of a number of human leukaemic and solid tumor cell lines.
生物活性的倍半萜内酯γ-羟基丁烯内酯15,18-双表-对映-克拉多珊瑚烷A和B（1和2）以及15-表-对映-克拉多珊瑚烷A和B（57和55）由对映-卤米酸合成。合成的倍半萜醇2、55、57和59抑制多种人白血病和实体瘤细胞系的细胞增殖（IC(50)约为2 μM）。
