从海洋海绵Spongia sp.中分离得到的三种新型细胞毒性倍半萜

Three new cytotoxic sesterterpenes from a marine sponge Spongia sp.

作者信息

Tsukamoto Sachiko, Miura Shunsuke, van Soest Rob W M, Ohta Tomihisa

机构信息

Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi, Kanazawa 920-0934, Japan.

出版信息

J Nat Prod. 2003 Mar;66(3):438-40. doi: 10.1021/np020497l.

DOI:10.1021/np020497l

PMID:12662110

Abstract

Three new sesterterpenes (1-3) were isolated from a marine sponge of the genus Spongia, and their structures were determined on the basis of spectroscopic analysis. The compounds 1-3 exhibited cytotoxicity against HeLa cells with IC(50) values of 19.5, 15.0, and 5.3 microg/mL, respectively.

摘要

从一种海绵属的海洋海绵中分离出三种新的倍半萜（1-3），并通过光谱分析确定了它们的结构。化合物1-3对HeLa细胞表现出细胞毒性，其半数抑制浓度（IC50）值分别为19.5、15.0和5.3微克/毫升。