Morphol Embryol (Bucur). 1975;21(3):187-96.
The recent data concerning the action of carcinogens and cocarcinogens, as well as the role of host factors in the development of lung carcinomas are discussed in relation to 2500 studied cases. The role of basal cell hyperplasia and of metaplastic factors is emphasized. Two developmental patterns could be observed: one characterized by the persistent action of carcinogens on a substrate similar or less different as to the normal one, giving rise to the microcellular, pleomorphous and epidermoid carcinomas, and the other related to the pre-existence of fibrous lesions in the lung which enhance the accumulation of carcinogens and provide for the cylindrocubic, bronchioloalveolar carcinomas and for the pseudoglandular zones of pleomorphous ones. In these views a histogenetic nomenclature and classification of lung carcinomas is proposed.
结合2500例研究病例，讨论了近期有关致癌物和促癌物作用以及宿主因素在肺癌发生中作用的数据。强调了基底细胞增生和化生因素的作用。可以观察到两种发展模式：一种以致癌物在与正常组织相似或差异较小的底物上持续作用为特征，产生微细胞型、多形性和表皮样癌；另一种与肺中纤维性病变的预先存在有关，这些病变会增强致癌物的积累，并导致柱状立方型、细支气管肺泡癌以及多形性癌的假腺区。基于这些观点，提出了肺癌的组织发生学命名和分类。
