Eskenasy A
Morphol Embryol (Bucur). 1982 Jan-Mar;28(1):35-45.
An analysis of the so-called giant cell carcinoma of the lung was performed in the light of eight new cases (five macrocellular and three cylindrocubic carcinomas) with different proportions of giant cells, and of a quantitative study of giant cells within the structure of 60 lung carcinomas, fifteen of each basic type of proliferation. Taking into account these data and those of the literature, it was concluded that giant cell carcinomas do not form either a basic type or a variant (subtype) of one of the lung carcinoma types, as suggested by WHO's typing (macrocellular). They represent, in author's conception, only particular forms of neoplastic proliferation in the lung, in which special conditions arising during the prolonged promotion phase influence mitosis, differentiation and/or maturation and modulation of cells composing the proliferating neoplastic foci. The large variations in the amount of giant cells also reflect these intervening actions.
根据8例新病例（5例大细胞癌和3例圆柱立方细胞癌）中巨细胞比例不同的情况，以及对60例肺癌结构内巨细胞的定量研究（每种基本增殖类型各15例），对所谓的肺巨细胞癌进行了分析。考虑到这些数据以及文献中的数据，得出的结论是，正如世界卫生组织的分型（大细胞型）所暗示的那样，巨细胞癌既不是一种基本类型，也不是肺癌类型之一的变体（亚型）。在作者看来，它们仅代表肺肿瘤增殖的特殊形式，其中在长期促进阶段出现的特殊条件会影响构成增殖性肿瘤病灶的细胞的有丝分裂、分化和/或成熟及调节。巨细胞数量的巨大差异也反映了这些干预作用。
